BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PVR
CD155, HVED, NECL5, Necl-5, PVS, TAGE4
poliovirus receptor
GO Process (8)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- adherens junction organization [TAS]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- positive regulation of natural killer cell mediated cytotoxicity [IMP]
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [IMP]
- regulation of immune response [TAS]
- susceptibility to T cell mediated cytotoxicity [IDA]
- susceptibility to natural killer cell mediated cytotoxicity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- cell line: hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID