BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PMAIP1
APR, NOXA
phorbol-12-myristate-13-acetate-induced protein 1
GO Process (21)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- T cell homeostasis [ISS]
- apoptotic process [IMP, TAS]
- cellular response to glucose starvation [IMP]
- cellular response to hypoxia [IEP]
- defense response to virus [IDA]
- intrinsic apoptotic signaling pathway [IDA, TAS]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- negative regulation of mitochondrial membrane potential [ISS]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- positive regulation of glucose metabolic process [IDA]
- positive regulation of intrinsic apoptotic signaling pathway [IDA, TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of protein oligomerization [IDA]
- positive regulation of release of cytochrome c from mitochondria [IDA, IMP]
- proteasomal protein catabolic process [IDA]
- reactive oxygen species metabolic process [IDA]
- regulation of mitochondrial membrane permeability [IDA]
- response to dsRNA [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID