BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PER2
FASPS, FASPS1
period circadian clock 2
GO Process (22)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- circadian regulation of translation [ISS]
- circadian rhythm [TAS]
- fatty acid metabolic process [ISS]
- gluconeogenesis [ISS]
- glycogen biosynthetic process [ISS]
- histone H3 deacetylation [ISS]
- lactate biosynthetic process [ISS]
- negative regulation of circadian rhythm [ISS]
- negative regulation of fat cell proliferation [ISS]
- negative regulation of protein ubiquitination [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- negative regulation of transcription regulatory region DNA binding [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- regulation of cell cycle [ISS]
- regulation of circadian rhythm [ISS]
- regulation of glutamate uptake involved in transmission of nerve impulse [ISS]
- regulation of insulin secretion [ISS]
- regulation of neurogenesis [ISS]
- regulation of vasoconstriction [ISS]
- response to ischemia [ISS]
- white fat cell differentiation [ISS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID