BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
BCL10
CARMEN, CIPER, CLAP, IMD37, c-E10, mE10, RP11-234D19.2
B-cell CLL/lymphoma 10
GO Process (23)
GO Function (14)
GO Component (11)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell receptor signaling pathway [IDA, TAS]
- adaptive immune response [TAS]
- cell death [IDA]
- cellular response to mechanical stimulus [IEP]
- innate immune response [IEP, TAS]
- interleukin-6 biosynthetic process [NAS]
- lymphotoxin A biosynthetic process [NAS]
- negative regulation of mature B cell apoptotic process [IDA]
- neural tube closure [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [IDA]
- positive regulation of interleukin-8 biosynthetic process [IMP]
- positive regulation of mast cell cytokine production [NAS]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein homooligomerization [ISS, TAS]
- protein oligomerization [IPI]
- response to food [IDA]
- response to molecule of bacterial origin [IEP]
- toll-like receptor signaling pathway [IC]
Gene Ontology Molecular Function- NF-kappaB binding [IDA]
- enzyme binding [IPI]
- kinase activator activity [IDA]
- kinase binding [IPI]
- protease binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase B binding [IPI]
- protein kinase binding [IDA]
- protein self-association [IPI]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin protein ligase binding [IPI]
- NF-kappaB binding [IDA]
- enzyme binding [IPI]
- kinase activator activity [IDA]
- kinase binding [IPI]
- protease binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase B binding [IPI]
- protein kinase binding [IDA]
- protein self-association [IPI]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID