BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
HIF1AN
FIH1
hypoxia inducible factor 1, alpha subunit inhibitor
GO Process (10)
GO Function (13)
GO Component (5)
Gene Ontology Biological Process
- cellular response to hypoxia [TAS]
- negative regulation of Notch signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA]
- oxidation-reduction process [IDA]
- peptidyl-asparagine hydroxylation [IDA, IMP]
- peptidyl-aspartic acid hydroxylation [IDA]
- peptidyl-histidine hydroxylation [IDA]
- positive regulation of myoblast differentiation [IDA]
- positive regulation of vasculogenesis [NAS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
Gene Ontology Molecular Function- NF-kappaB binding [IPI]
- Notch binding [IPI]
- ankyrin repeat binding [IPI]
- carboxylic acid binding [IDA]
- cofactor binding [IDA]
- iron ion binding [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [EXP]
- oxygen sensor activity [NAS]
- peptidyl-asparagine 3-dioxygenase activity [IDA, IMP]
- peptidyl-histidine dioxygenase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- zinc ion binding [IDA]
- NF-kappaB binding [IPI]
- Notch binding [IPI]
- ankyrin repeat binding [IPI]
- carboxylic acid binding [IDA]
- cofactor binding [IDA]
- iron ion binding [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [EXP]
- oxygen sensor activity [NAS]
- peptidyl-asparagine 3-dioxygenase activity [IDA, IMP]
- peptidyl-histidine dioxygenase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Ubiquitin-mediated proteolysis of HuR by heat shock.
The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently reduces HuR levels, thereby altering the expression of HuR target mRNAs. HS did not change HuR mRNA levels or de novo translation, ... [more]
EMBO J. May. 06, 2009; 28(9);1271-82 [Pubmed: 19322201]
Throughput
- High Throughput
Ontology Terms
- cell line: hela cell (BTO:0000567) [cervical adenocarcinoma (DOID:3702)]
Curated By
- BioGRID