BAIT

RLIM

NY-REN-43, RNF12, CTD-2530H13.3
ring finger protein, LIM domain interacting
UPS Project
Homo sapiens
PREY

REXO1

ELOABP1, EloA-BP1, REX1, TCEB3BP1
REX1, RNA exonuclease 1 homolog (S. cerevisiae)
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Homo sapiens

Biochemical Activity (Ubiquitination)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation.

Gontan C, Achame EM, Demmers J, Barakat TS, Rentmeester E, van IJcken W, Grootegoed JA, Gribnau J

Evolution of the mammalian sex chromosomes has resulted in a heterologous X and Y pair, where the Y chromosome has lost most of its genes. Hence, there is a need for X-linked gene dosage compensation between XY males and XX females. In placental mammals, this is achieved by random inactivation of one X chromosome in all female somatic cells. Upregulation ... [more]

Nature May. 17, 2012; 485(7398);386-90 [Pubmed: 22596162]

Throughput

  • Low Throughput

Curated By

  • BioGRID