ALP14
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IDA]
- cytoplasmic microtubule organization [IMP]
- establishment or maintenance of cell polarity regulating cell shape [IMP]
- microtubule cytoskeleton organization [IMP]
- mitotic sister chromatid segregation [IMP]
- spindle assembly involved in mitosis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAL3
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IGI, IMP]
- cellular protein localization [IMP]
- dynein-driven meiotic oscillatory nuclear movement [IMP]
- gamma-tubulin complex localization [IMP]
- karyogamy [IMP]
- microtubule polymerization [IMP]
- microtubule-based movement [IMP]
- mitotic spindle stabilization [IGI]
- nuclear migration involved in conjugation with cellular fusion [IMP]
- positive regulation of ATPase activity [IDA]
- protein localization to microtubule [IDA, IMP]
- regulation of filamentous growth [IMP]
- spindle assembly involved in mitosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Fission yeast Alp14 is a dose dependent plus end tracking microtubule polymerase.
XMAP215/Dis1 proteins are conserved tubulin-binding TOG domain proteins that regulate microtubule (MT) plus end dynamics. Here, we show that Alp14, a XMAP215 orthologue in fission yeast Schizosaccharomyces pombe, has properties of a MT polymerase. In vivo, Alp14 localizes to growing MT plus ends, in a manner independent of Mal3 (EB1). alp14 null mutants display short interphase MTs with twofold slower ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 1B.Apl14 co-localizes with +TIP proteins.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAL3 ALP14 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -15.3579 | BioGRID | 527987 | |
| MAL3 ALP14 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 800005 |
Curated By
- BioGRID