BAIT
CUT14
smc2, SPBP4H10.06c
condensin complex subunit Cut14
GO Process (2)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
RAD52
rad22, rad22A, SPAC30D11.10
DNA recombination protein Rad52 (previously Rad22)
GO Process (7)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- DNA recombinase assembly [NAS]
- double-strand break repair via homologous recombination [IGI]
- gene conversion at mating-type locus, DNA repair synthesis [IMP]
- homologous recombination-dependent replication fork processing [IMP]
- mating type switching [IMP]
- meiotic DNA repair synthesis [IMP]
- mitotic recombination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.
Condensin is required for chromosome dynamics and diverse DNA metabolism. How condensin works, however, is not well understood. Condensin contains two structural maintenance of chromosomes (SMC) subunits with the terminal globular domains connected to coiled-coil that is interrupted by the central hinge. Heterotrimeric non-SMC subunits regulate SMC. We identified a novel fission yeast SMC hinge mutant, cut14-Y1, which displayed defects ... [more]
Open Biol Dec. 01, 2011; 1(4);110023 [Pubmed: 22645654]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- cut14-Y1, no viable double mutant through tetrad dissections
Curated By
- BioGRID