A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.

Akai Y, Kurokawa Y, Nakazawa N, Tonami-Murakami Y, Suzuki Y, Yoshimura SH, Iwasaki H, Shiroiwa Y, Nakamura T, Shibata E, Yanagida M

Condensin is required for chromosome dynamics and diverse DNA metabolism. How condensin works, however, is not well understood. Condensin contains two structural maintenance of chromosomes (SMC) subunits with the terminal globular domains connected to coiled-coil that is interrupted by the central hinge. Heterotrimeric non-SMC subunits regulate SMC. We identified a novel fission yeast SMC hinge mutant, cut14-Y1, which displayed defects ... [more]

Open Biol Dec. 01, 2011; 1(4);110023 [Pubmed: 22645654]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Additional Notes

cut14-Y1, no viable double mutant through tetrad dissections

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
PKU70 CUT14	Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.	Tanaka A (2012)	Low	-	BioGRID	736056

Curated By

BioGRID

Interaction Summary

CUT14

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATPase activity [ISM]

Gene Ontology Cellular Component

PKU70