smc2, SPBP4H10.06c
condensin complex subunit Cut14
GO Process (2)
GO Function (1)
GO Component (5)

Gene Ontology Molecular Function

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.

Akai Y, Kurokawa Y, Nakazawa N, Tonami-Murakami Y, Suzuki Y, Yoshimura SH, Iwasaki H, Shiroiwa Y, Nakamura T, Shibata E, Yanagida M

Condensin is required for chromosome dynamics and diverse DNA metabolism. How condensin works, however, is not well understood. Condensin contains two structural maintenance of chromosomes (SMC) subunits with the terminal globular domains connected to coiled-coil that is interrupted by the central hinge. Heterotrimeric non-SMC subunits regulate SMC. We identified a novel fission yeast SMC hinge mutant, cut14-Y1, which displayed defects ... [more]

Open Biol Dec. 01, 2011; 1(4);110023 [Pubmed: 22645654]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Additional Notes

  • cut14-Y1, no viable double mutant through tetrad dissections

Curated By

  • BioGRID