A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.

Akai Y, Kurokawa Y, Nakazawa N, Tonami-Murakami Y, Suzuki Y, Yoshimura SH, Iwasaki H, Shiroiwa Y, Nakamura T, Shibata E, Yanagida M

Condensin is required for chromosome dynamics and diverse DNA metabolism. How condensin works, however, is not well understood. Condensin contains two structural maintenance of chromosomes (SMC) subunits with the terminal globular domains connected to coiled-coil that is interrupted by the central hinge. Heterotrimeric non-SMC subunits regulate SMC. We identified a novel fission yeast SMC hinge mutant, cut14-Y1, which displayed defects ... [more]

Open Biol Dec. 01, 2011; 1(4);110023 [Pubmed: 22645654]

Throughput

Low Throughput

Ontology Terms

vegetative growth (APO:0000106)
resistance to chemicals (APO:0000087)

Additional Notes

double mutant with cut14-Y1 shows temperature-sensitivity, growth defect on hydroxyurea and UV

Curated By

BioGRID

Interaction Summary

CUT14

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATPase activity [ISM]

Gene Ontology Cellular Component

SWI1