Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Requirement of fission yeast Cid14 in polyadenylation of rRNAs.

Win TZ, Draper S, Read RL, Pearce J, Norbury CJ, Wang SW

Polyadenylation in eukaryotes is conventionally associated with increased nuclear export, translation, and stability of mRNAs. In contrast, recent studies suggest that the Trf4 and Trf5 proteins, members of a widespread family of noncanonical poly(A) polymerases, share an essential function in Saccharomyces cerevisiae that involves polyadenylation of nuclear RNAs as part of a pathway of exosome-mediated RNA turnover. Substrates for this ... [more]

Mol. Cell. Biol. Mar. 01, 2006; 26(5);1710-21 [Pubmed: 16478992]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: chromosome/plasmid maintenance (APO:0000143)

Additional Notes

  • double mutants show increased defects in sister centromere cohesion

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
CID12 NDA3
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
425715

Curated By

  • BioGRID