BAIT
ZFAND2A
AA407930, AU016206, Airap
zinc finger, AN1-type domain 2A
GO Process (2)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HSPA8
2410008N15Rik, Hsc70, Hsc71, Hsc73, Hsp73, Hspa10
heat shock protein 8
GO Process (10)
GO Function (13)
GO Component (18)
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO]
- chaperone mediated protein folding requiring cofactor [IGI, ISO]
- chaperone-mediated protein folding [ISO]
- clathrin coat disassembly [IGI]
- negative regulation of fibril organization [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of mRNA splicing, via spliceosome [IMP]
- protein folding [IDA]
- protein refolding [ISO]
- regulation of cell cycle [IDA]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [IDA, ISO]
- G-protein coupled receptor binding [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [IPI, ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [IDA, ISO]
- G-protein coupled receptor binding [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [IPI, ISO]
Gene Ontology Cellular Component
- Prp19 complex [ISO]
- blood microparticle [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [IDA, ISO]
- focal adhesion [ISO]
- intracellular [IDA]
- membrane [ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- protein complex [ISO]
- ribonucleoprotein complex [ISO]
- synaptic vesicle [ISO]
- terminal bouton [ISO]
- ubiquitin ligase complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity.
Protein misfolding caused by exposure to arsenite is associated with transcriptional activation of the AIRAP gene. We report here that AIRAP is an arsenite-inducible subunit of the proteasome's 19S cap that binds near PSMD2 at the 19S base. Compared to the wild-type, knockout mouse cells or C. elegans lacking AIRAP accumulate more polyubiquitylated proteins and exhibit higher levels of stress ... [more]
Mol. Cell Sep. 15, 2006; 23(6);875-85 [Pubmed: 16973439]
Throughput
- Low Throughput
Curated By
- BioGRID