HDAC3
Gene Ontology Biological Process
- cellular response to fluid shear stress [ISO]
- chromatin modification [TAS]
- circadian regulation of gene expression [IGI]
- histone deacetylation [IGI, IMP, ISO]
- negative regulation of JNK cascade [ISO]
- negative regulation of cardiac muscle cell differentiation [IMP]
- negative regulation of interleukin-1 production [ISO]
- negative regulation of protein export from nucleus [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of tumor necrosis factor production [ISO]
- positive regulation of TOR signaling [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of type B pancreatic cell apoptotic process [ISO]
- protein deacetylation [IDA, ISO]
- regulation of mitotic cell cycle [IDA]
- regulation of multicellular organism growth [IGI]
- regulation of protein stability [ISO]
- spindle assembly [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- GTPase binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA, ISO]
- cyclin binding [ISO]
- enzyme binding [ISO]
- histone deacetylase activity [ISO, TAS]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IDA, ISO, TAS]
- DNA binding [IDA]
- GTPase binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA, ISO]
- cyclin binding [ISO]
- enzyme binding [ISO]
- histone deacetylase activity [ISO, TAS]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IDA, ISO, TAS]
Gene Ontology Cellular Component
SP1
Gene Ontology Biological Process
- definitive hemopoiesis [IGI]
- embryonic camera-type eye morphogenesis [IGI]
- embryonic placenta development [IGI]
- embryonic process involved in female pregnancy [IGI]
- embryonic skeletal system development [IGI]
- enucleate erythrocyte differentiation [IGI]
- in utero embryonic development [IGI]
- liver development [IGI]
- lung development [IGI]
- megakaryocyte differentiation [IGI]
- ossification [IGI]
- positive regulation by host of viral transcription [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [IMP, ISO]
- transcription from RNA polymerase II promoter [IDA]
- trophectodermal cell differentiation [IGI]
Gene Ontology Molecular Function- DNA binding [IDA, ISO, ISS]
- HMG box domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- bHLH transcription factor binding [IPI]
- core promoter proximal region sequence-specific DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- double-stranded DNA binding [IDA, ISO]
- enhancer binding [IDA]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA, ISO, ISS]
- HMG box domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- bHLH transcription factor binding [IPI]
- core promoter proximal region sequence-specific DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- double-stranded DNA binding [IDA, ISO]
- enhancer binding [IDA]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1.
We have shown the induction of histone deacetylase 3 (HDAC3) in antigen-stimulated rat basophilic leukemia cells via NF-kB. We investigated the role of HDAC3 in allergic skin inflammation. We used BALB/c mouse model of triphasic cutaneous anaphylaxis (TpCR) and passive cutaneous anaphylaxis (PCA) to examine role of HDAC3 in allergic skin inflammation. Triphasic cutaneous reaction (TpCR) involved induction of HDAC3 ... [more]
Throughput
- Low Throughput
Additional Notes
- figure S3A.
Curated By
- BioGRID