BAIT

EED

HEED, WAIT1
embryonic ectoderm development
Cell Cycle - Senescence Project
Synthetic Protein Interaction Project
UPS Project
GO Process (1)
GO Function (3)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

EHMT1

EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KMT1D, bA188C12.1, RP11-188C12.1
euchromatic histone-lysine N-methyltransferase 1
Autism spectrum disorder (ASD) Project
Cell Cycle - Senescence Project
Homo sapiens

Protein-RNA

An interaction is detected between and protein and an RNA in vitro.

Publication

Intronic RNAs mediate EZH2 regulation of epigenetic targets.

Guil S, Soler M, Portela A, Carrere J, Fonalleras E, Gomez A, Villanueva A, Esteller M

Epigenetic deregulation at a number of genomic loci is one of the hallmarks of cancer. A role for some RNA molecules in guiding repressive polycomb complex PRC2 to specific chromatin regions has been proposed. Here we use an in vivo cross-linking method to detect and identify direct PRC2-RNA interactions in human cancer cells, revealing a number of intronic RNA sequences ... [more]

Unknown Jun. 03, 2012; 0(0); [Pubmed: 22659877]

Throughput

  • Low Throughput

Additional Notes

  • figure 1b. stable RNA-EZH2 interaction is only possible in the presence of other PRC2 component, EED.

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
EED EHMT1
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High-BioGRID
-

Curated By

  • BioGRID