BAIT
SMYD3
KMT3E, ZMYND1, ZNFN3A1, bA74P14.1, RP11-49H10.1
SET and MYND domain containing 3
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
EZH2
ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2
enhancer of zeste 2 polycomb repressive complex 2 subunit
GO Process (12)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- chromatin organization [TAS]
- histone H3-K27 methylation [IDA]
- negative regulation of gene expression, epigenetic [IDA]
- negative regulation of retinoic acid receptor signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of epithelial to mesenchymal transition [IDA]
- positive regulation of protein serine/threonine kinase activity [IDA]
- regulation of circadian rhythm [IMP]
- regulation of transcription, DNA-templated [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
Intronic RNAs mediate EZH2 regulation of epigenetic targets.
Epigenetic deregulation at a number of genomic loci is one of the hallmarks of cancer. A role for some RNA molecules in guiding repressive polycomb complex PRC2 to specific chromatin regions has been proposed. Here we use an in vivo cross-linking method to detect and identify direct PRC2-RNA interactions in human cancer cells, revealing a number of intronic RNA sequences ... [more]
Unknown Jun. 03, 2012; 0(0); [Pubmed: 22659877]
Throughput
- Low Throughput
Additional Notes
- figure 1c.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EZH2 SMYD3 | Protein-RNA Protein-RNA An interaction is detected between and protein and an RNA in vitro. | Low | - | BioGRID | 666364 |
Curated By
- BioGRID