BAIT
RPN502
rpn5, rpn5-b, SPAPB8E5.02c
19S proteasome regulatory subunit Rpn502
GO Process (2)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
RPN11
bfr2, mts5, pad1, sks1, SPAC31G5.13
19S proteasome regulatory subunit Rpn11
GO Process (3)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Rpn5 is a conserved proteasome subunit and required for proper proteasome localization and assembly.
Proper function of the 26 S proteasome requires assembly of the regulatory complex, which is composed of the lid and base subcomplexes. We characterized Rpn5, a lid subunit, in fission yeast. We show that Rpn5 associates with the proteasome rpn5. Deletion (rpn5Delta) exacerbates the growth defects in proteasome mutants, leading to mitotic abnormalities, which correlate with accumulation of polyubiquitinated proteins, ... [more]
J. Biol. Chem. Aug. 15, 2003; 278(33);30669-76 [Pubmed: 12783882]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- rpn5/pad1 mutants are lethal
Curated By
- BioGRID