STY1
Gene Ontology Biological Process
- G1 cell cycle arrest in response to nitrogen starvation [IMP]
- G1 to G0 transition [IMP]
- MAPK cascade in response to starvation [IMP]
- MAPK cascade involved in osmosensory signaling pathway [IDA, IMP]
- cellular response to cation stress [IGI]
- cellular response to nitrogen starvation [IMP]
- mRNA export from nucleus in response to heat stress [IMP]
- mitotic cell cycle arrest in response to nitrogen starvation [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of transcription factor import into nucleus in response to oxidative stress [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP]
- regulation of DNA binding [IDA]
- regulation of cAMP-mediated signaling [IMP]
- regulation of cAMP-mediated signaling by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of cell shape involved in G1 to G0 transition [IMP]
- regulation of chromatin assembly [IMP]
- regulation of chromatin disassembly [IMP]
- regulation of histone acetylation [IMP]
- regulation of mRNA stability involved in cellular response to UV [IMP]
- regulation of meiotic cell cycle [IMP]
- regulation of reciprocal meiotic recombination [IMP]
- regulation of translation in response to nitrogen starvation [IDA]
- regulation of translation in response to osmotic stress [IDA, IMP]
- regulation of translation in response to oxidative stress [IDA, IMP]
- stress granule assembly [IMP]
- stress granule disassembly [IMP]
- stress-activated MAPK cascade [IMP]
Gene Ontology Molecular Function
HAL4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase Spc1/Sty1 and the Hal4 protein kinase.
Stress-activated protein kinases (SAPKs), members of a mitogen-activated protein kinase (MAPK) subfamily, are highly conserved among eukaryotes. Studies of yeasts demonstrated that SAPKs play pivotal roles in survival responses to high osmolarity, oxidative stress, and heat shock. Here we report a novel physiological role of the fission yeast Spc1 SAPK in cellular resistance to certain cations, such as Na(+), Li(+), ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HAL4 STY1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| HAL4 STY1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 247820 |
Curated By
- BioGRID