BAIT
ANKRA2
ANKRA
ankyrin repeat, family A (RFXANK-like), 2
GO Process (1)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PDE3B
HcGIP1, cGIPDE1
phosphodiesterase 3B, cGMP-inhibited
GO Process (9)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cAMP catabolic process [IEP]
- cellular response to insulin stimulus [ISS]
- insulin receptor signaling pathway [TAS]
- negative regulation of angiogenesis [IMP]
- negative regulation of cAMP-mediated signaling [IC]
- negative regulation of cell adhesion [IMP]
- negative regulation of cell adhesion mediated by integrin [IC]
- negative regulation of lipid catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock.
Ankyrin repeat family A protein 2 (ANKRA2) interacts with the plasma membrane receptor megalin and the class IIa histone deacetylases HDAC4 and HDAC5. We report that the ankyrin repeat domains of ANKRA2 and its close paralog regulatory factor X-associated ankyrin-containing protein (RFXANK) recognize a PxLPxI/L motif found in diverse binding proteins, including HDAC4, HDAC5, HDAC9, megalin, and regulatory factor X, ... [more]
Sci Signal Jun. 01, 2012; 5(226);ra39 [Pubmed: 22649097]
Throughput
- Low Throughput
Additional Notes
- figure 7A. unphosphorylated peptides (PS/TLP consensus).
Curated By
- BioGRID