MRTL, MYCC, bHLHe39, c-Myc
v-myc avian myelocytomatosis viral oncogene homolog
GO Process (39)
GO Function (9)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Dosage Lethality

A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.


Functional genomics identifies therapeutic targets for MYC-driven cancer.

Toyoshima M, Howie HL, Imakura M, Walsh RM, Annis JE, Chang AN, Frazier J, Chau BN, Loboda A, Linsley PS, Cleary MA, Park JR, Grandori C

MYC oncogene family members are broadly implicated in human cancers, yet are considered "undruggable" as they encode transcription factors. MYC also carries out essential functions in proliferative tissues, suggesting that its inhibition could cause severe side effects. We elected to identify synthetic lethal interactions with c-MYC overexpression (MYC-SL) in a collection of ∼3,300 druggable genes, using high-throughput siRNA screening. Of ... [more]

Proc. Natl. Acad. Sci. U.S.A. Jun. 12, 2012; 109(24);9545-50 [Pubmed: 22623531]


  • High Throughput

Additional Notes

  • table S1, figure 1.

Curated By

  • BioGRID