BAIT
MMP9
AW743869, B/MMP9, Clg4b, MMP-9, pro-MMP-9, RP23-61O3.10-001
matrix metallopeptidase 9
GO Process (19)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- cellular response to cell-matrix adhesion [ISO]
- collagen catabolic process [IDA, ISO]
- embryo implantation [IDA]
- extracellular matrix organization [IGI, IMP]
- negative regulation of cation channel activity [ISO]
- negative regulation of fibroblast proliferation [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of keratinocyte migration [ISO]
- positive regulation of leukocyte migration [ISO]
- positive regulation of receptor binding [ISO]
- positive regulation of synaptic plasticity [ISO]
- protein oligomerization [ISO]
- proteolysis [IDA, ISO]
- response to drug [ISO]
- response to oxidative stress [ISO]
- skeletal system development [IGI, IMP]
- tissue remodeling [ISO]
- transformation of host cell by virus [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SMAD3
AU022421, Madh3, RP23-63E8.1
SMAD family member 3
GO Process (73)
GO Function (31)
GO Component (11)
Gene Ontology Biological Process
- SMAD protein complex assembly [ISO]
- SMAD protein signal transduction [IGI]
- T cell activation [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISO]
- activin receptor signaling pathway [ISO]
- cell cycle arrest [ISO]
- cell-cell junction organization [ISO]
- developmental growth [IGI]
- embryonic cranial skeleton morphogenesis [IGI]
- embryonic foregut morphogenesis [IGI]
- embryonic pattern specification [IGI]
- endoderm development [IGI]
- evasion or tolerance of host defenses by virus [ISO]
- extrinsic apoptotic signaling pathway [ISO]
- gastrulation [IGI]
- heart looping [IGI]
- immune response [ISO]
- immune system development [IGI]
- in utero embryonic development [IGI]
- intracellular signal transduction [ISO]
- lens fiber cell differentiation [IMP]
- liver development [IGI]
- mesoderm formation [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of inflammatory response [IMP]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of osteoblast differentiation [IGI]
- negative regulation of osteoblast proliferation [IMP]
- negative regulation of protein catabolic process [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of wound healing [IMP]
- nodal signaling pathway [ISO]
- osteoblast development [IGI]
- osteoblast differentiation [IMP]
- paraxial mesoderm morphogenesis [IMP]
- pericardium development [IGI]
- positive regulation of alkaline phosphatase activity [ISO]
- positive regulation of bone mineralization [ISO]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of catenin import into nucleus [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of chondrocyte differentiation [IMP]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of interleukin-1 beta production [ISO]
- positive regulation of positive chemotaxis [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta3 production [ISO]
- protein stabilization [ISO]
- regulation of binding [IDA]
- regulation of epithelial cell proliferation [IMP]
- regulation of immune response [IMP]
- regulation of striated muscle tissue development [IDA]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transforming growth factor beta receptor signaling pathway [IDA, ISO]
- regulation of transforming growth factor beta2 production [ISO]
- response to hypoxia [ISO]
- signal transduction involved in regulation of gene expression [ISO]
- skeletal system development [IGI]
- somitogenesis [IMP]
- thyroid gland development [IGI]
- transcription from RNA polymerase II promoter [ISO, TAS]
- transdifferentiation [ISO]
- transforming growth factor beta receptor signaling pathway [IDA, ISO]
- transport [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISO]
- SMAD binding [ISO]
- bHLH transcription factor binding [ISO]
- beta-catenin binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- collagen binding [IPI]
- core promoter proximal region sequence-specific DNA binding [ISO]
- double-stranded DNA binding [IDA]
- enzyme binding [ISO]
- identical protein binding [ISO]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein binding transcription factor activity [ISO]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase binding [ISO]
- zinc ion binding [ISO]
- DNA binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISO]
- SMAD binding [ISO]
- bHLH transcription factor binding [ISO]
- beta-catenin binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- collagen binding [IPI]
- core promoter proximal region sequence-specific DNA binding [ISO]
- double-stranded DNA binding [IDA]
- enzyme binding [ISO]
- identical protein binding [ISO]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein binding transcription factor activity [ISO]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice.
Previous studies have found that inappropriate elevation of matrix metalloproteinase-9 (MMP9) expression and activity is coincident with early onset of emphysema in Smad3-null mice. Herein, we further investigated the role of increased MMP9 in emphysema pathogenesis and the related molecular regulatory mechanisms of elevated MMP9 in Smad3-null lung. Genetic blockade of MMP9 in Smad3-null mice significantly attenuated emphysema pathology, but ... [more]
Unknown May. 18, 2012; 0(0); [Pubmed: 22610349]
Throughput
- Low Throughput
Additional Notes
- figure 1.
Curated By
- BioGRID