Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells.

Turtoi A, Mottet D, Matheus N, Dumont B, Peixoto P, Hennequiere V, Deroanne C, Colige A, De Pauw E, Bellahcene A, Castronovo V

Histone deacetylases (HDACs) are a family of 18 enzymes that deacetylate lysine residues of both histone and nonhistone proteins and to a large extent govern the process of angiogenesis. Previous studies have shown that specific inhibition of HDAC7 blocks angiogenesis both in vitro and in vivo. However, the underlying molecular mechanisms are not fully understood and hence preclude any meaningful ... [more]

Unknown May. 15, 2012; 0(0); [Pubmed: 22584896]

Throughput

  • Low Throughput

Additional Notes

  • figure 2. inhibition by siRNA for both proteins.
  • figure 3. Impairment of HUVEC migration following HDAC7 depletion is dependent on AKAP12 protein expression.

Curated By

  • BioGRID