TRP53BP1
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II transcription cofactor activity [ISO]
- damaged DNA binding [IDA]
- methylated histone binding [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- telomeric DNA binding [IDA]
- transcription factor binding [TAS]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II transcription cofactor activity [ISO]
- damaged DNA binding [IDA]
- methylated histone binding [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- telomeric DNA binding [IDA]
- transcription factor binding [TAS]
Gene Ontology Cellular Component
TERF1
Gene Ontology Biological Process
- age-dependent telomere shortening [ISO]
- mitotic spindle assembly checkpoint [ISO]
- negative regulation of DNA replication [ISO]
- negative regulation of telomerase activity [ISO]
- negative regulation of telomere maintenance via telomerase [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of microtubule polymerization [ISO]
- positive regulation of mitosis [ISO]
- positive regulation of mitotic cell cycle [ISO]
- protein homooligomerization [ISO]
- telomere maintenance via telomerase [ISO]
- telomere maintenance via telomere shortening [IBA]
- telomeric loop formation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Removal of shelterin reveals the telomere end-protection problem.
The telomere end-protection problem is defined by the aggregate of DNA damage signaling and repair pathways that require repression at telomeres. To define the end-protection problem, we removed the whole shelterin complex from mouse telomeres through conditional deletion of TRF1 and TRF2 in nonhomologous end-joining (NHEJ) deficient cells. The data reveal two DNA damage response pathways not previously observed upon ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 4. 53BP1 blocks 5-end resection and shortening of shelterin-free telomeres.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TRP53BP1 TERF1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 668590 | |
| TRP53BP1 TERF1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 668589 | |
| TRP53BP1 TERF1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 668591 |
Curated By
- BioGRID