BAIT
TRP53BP1
53BP1, Tp53bp1, m53BP1, p53BP1, RP23-437L13.2
transformation related protein 53 binding protein 1
GO Process (5)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II transcription cofactor activity [ISO]
- damaged DNA binding [IDA]
- methylated histone binding [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- telomeric DNA binding [IDA]
- transcription factor binding [TAS]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II transcription cofactor activity [ISO]
- damaged DNA binding [IDA]
- methylated histone binding [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- telomeric DNA binding [IDA]
- transcription factor binding [TAS]
Gene Ontology Cellular Component
Mus musculus
PREY
TERF2
TRF2
telomeric repeat binding factor 2
GO Process (9)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- in utero embryonic development [IMP]
- negative regulation of telomere maintenance [ISO]
- positive regulation of telomere maintenance [IDA, IMP]
- protection from non-homologous end joining at telomere [IDA, IMP, ISO]
- protein localization to chromosome, telomeric region [ISO]
- telomere capping [ISO]
- telomere maintenance [IMP, ISO]
- telomere maintenance via telomere shortening [IBA]
- telomeric loop formation [IBA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Removal of shelterin reveals the telomere end-protection problem.
The telomere end-protection problem is defined by the aggregate of DNA damage signaling and repair pathways that require repression at telomeres. To define the end-protection problem, we removed the whole shelterin complex from mouse telomeres through conditional deletion of TRF1 and TRF2 in nonhomologous end-joining (NHEJ) deficient cells. The data reveal two DNA damage response pathways not previously observed upon ... [more]
Science May. 04, 2012; 336(6081);593-7 [Pubmed: 22556254]
Throughput
- Low Throughput
Additional Notes
- figure 4. 53BP1 blocks 5-end resection and shortening of shelterin-free telomeres.
Curated By
- BioGRID