BAIT
LIG4
5830471N16Rik, tiny
ligase IV, DNA, ATP-dependent
GO Process (28)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- DNA ligation [IDA, IMP, ISO]
- DNA ligation involved in DNA recombination [IMP]
- DNA ligation involved in DNA repair [IMP, ISO]
- DNA repair [IMP]
- T cell differentiation in thymus [IMP]
- T cell receptor V(D)J recombination [IMP]
- V(D)J recombination [IDA, IMP, ISO]
- cell proliferation [IMP]
- central nervous system development [IGI, IMP]
- chromosome organization [IGI]
- double-strand break repair [IGI, IMP, ISO]
- double-strand break repair via nonhomologous end joining [IMP, ISO]
- immunoglobulin V(D)J recombination [IMP]
- in utero embryonic development [IMP]
- isotype switching [IMP]
- lagging strand elongation [IBA]
- negative regulation of neuron apoptotic process [IGI, IMP]
- neuron apoptotic process [IGI]
- nucleotide-excision repair [IBA]
- nucleotide-excision repair, DNA gap filling [ISO]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of neurogenesis [IMP]
- pro-B cell differentiation [IMP]
- response to X-ray [ISO]
- response to gamma radiation [IMP]
- response to ionizing radiation [IMP]
- single strand break repair [ISO]
- somatic stem cell maintenance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TERF1
Pin2, Trbf1, Trf1
telomeric repeat binding factor 1
GO Process (13)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- age-dependent telomere shortening [ISO]
- mitotic spindle assembly checkpoint [ISO]
- negative regulation of DNA replication [ISO]
- negative regulation of telomerase activity [ISO]
- negative regulation of telomere maintenance via telomerase [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of microtubule polymerization [ISO]
- positive regulation of mitosis [ISO]
- positive regulation of mitotic cell cycle [ISO]
- protein homooligomerization [ISO]
- telomere maintenance via telomerase [ISO]
- telomere maintenance via telomere shortening [IBA]
- telomeric loop formation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Removal of shelterin reveals the telomere end-protection problem.
The telomere end-protection problem is defined by the aggregate of DNA damage signaling and repair pathways that require repression at telomeres. To define the end-protection problem, we removed the whole shelterin complex from mouse telomeres through conditional deletion of TRF1 and TRF2 in nonhomologous end-joining (NHEJ) deficient cells. The data reveal two DNA damage response pathways not previously observed upon ... [more]
Science May. 04, 2012; 336(6081);593-7 [Pubmed: 22556254]
Throughput
- Low Throughput
Additional Notes
- figure S4.
Curated By
- BioGRID