BAIT
GLI2
AW546128
GLI-Kruppel family member GLI2
GO Process (59)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- anatomical structure development [IGI, IMP]
- anatomical structure formation involved in morphogenesis [IGI]
- axon guidance [IMP]
- branching morphogenesis of an epithelial tube [IMP]
- cell differentiation [IMP]
- cell proliferation [IGI, ISO]
- cellular response to organic cyclic compound [IDA]
- cellular response to virus [ISO]
- cerebellar cortex morphogenesis [IGI, IMP]
- chondrocyte differentiation [IGI]
- cochlea morphogenesis [IMP]
- developmental growth [IMP]
- dorsal/ventral neural tube patterning [IDA, IMP]
- dorsal/ventral pattern formation [IGI]
- embryonic digestive tract development [IMP]
- embryonic digit morphogenesis [IMP]
- epidermal cell differentiation [ISO]
- floor plate formation [IMP]
- head development [IMP]
- heart development [IGI]
- hindbrain development [IGI, IMP]
- hindgut morphogenesis [IGI, IMP]
- in utero embryonic development [IMP]
- kidney development [IGI]
- lung development [IGI, IMP]
- mammary gland development [IMP]
- mammary gland duct morphogenesis [IMP]
- morphogenesis of an epithelium [IMP]
- negative regulation of chondrocyte differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- neural tube development [IMP]
- neuron development [IMP]
- notochord regression [IGI]
- odontogenesis of dentin-containing tooth [IGI, IMP]
- osteoblast development [IDA, IMP]
- osteoblast differentiation [IGI, ISO]
- pattern specification process [IGI, IMP]
- pituitary gland development [IGI]
- positive regulation of DNA replication [ISO]
- positive regulation of cell proliferation [IGI, IMP]
- positive regulation of neuron differentiation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- prostatic bud formation [IMP]
- proximal/distal pattern formation [IGI]
- regulation of smoothened signaling pathway [IMP]
- skeletal system development [IMP]
- smoothened signaling pathway [IGI, IMP, ISO]
- smoothened signaling pathway involved in dorsal/ventral neural tube patterning [IGI]
- smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [IGI, IMP]
- smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [IGI]
- smoothened signaling pathway involved in ventral spinal cord interneuron specification [IGI]
- spinal cord dorsal/ventral patterning [IGI, IMP]
- spinal cord motor neuron differentiation [IMP]
- spinal cord ventral commissure morphogenesis [IMP]
- transcription from RNA polymerase II promoter [IDA]
- tube development [IGI]
- ventral midline development [IGI, IMP]
- ventral spinal cord development [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription regulatory region DNA binding [IDA]
- zinc ion binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription regulatory region DNA binding [IDA]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
PIAS1
2900068C24Rik, Ddxbp1, GBP
protein inhibitor of activated STAT 1
GO Process (12)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- JAK-STAT cascade [ISA]
- mitotic S phase [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of nucleic acid-templated transcription [ISA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein sumoylation [ISO]
- positive regulation of smooth muscle cell differentiation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein sumoylation [IDA]
- protein-DNA complex assembly [ISO]
- regulation of cell proliferation [IMP]
Gene Ontology Molecular Function
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Small Ubiquitin-like Modifier (SUMO) Modification Inhibits GLI2 Protein Transcriptional Activity in Vitro and in Vivo.
The Gli transcription factors are key downstream mediators of the Hedgehog (Hh) signaling pathway. How the activities of Gli transcription factors are regulated by upstream Hh signaling events and protein modifications are not fully understood. Here we show that GLI2 is conjugated by small ubiquitin-like modifier (SUMO) at lysine residues 630 and 716 in the cell. The level of GLI2 ... [more]
J. Biol. Chem. Jun. 08, 2012; 287(24);20483-9 [Pubmed: 22549777]
Throughput
- Low Throughput
Additional Notes
- data not shown.
Curated By
- BioGRID