SIX1
Gene Ontology Biological Process
- anatomical structure development [IGI]
- aorta morphogenesis [IGI]
- branching involved in ureteric bud morphogenesis [IGI]
- cochlea morphogenesis [IMP]
- embryonic cranial skeleton morphogenesis [IGI]
- embryonic skeletal system morphogenesis [IGI]
- epithelial cell differentiation [IMP]
- facial nerve morphogenesis [IMP]
- fungiform papilla morphogenesis [IMP]
- generation of neurons [IMP]
- inner ear development [IMP]
- inner ear morphogenesis [IGI]
- kidney development [IMP]
- mesonephric tubule formation [IMP]
- metanephric mesenchyme development [IMP]
- middle ear morphogenesis [IMP]
- myoblast migration [IGI]
- myotome development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of branching involved in ureteric bud morphogenesis [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- neurogenesis [IMP]
- neuron fate specification [IGI]
- olfactory placode formation [IMP]
- organ induction [IMP]
- otic vesicle development [IGI, IMP]
- outflow tract morphogenesis [IGI]
- pattern specification process [IGI, IMP]
- pharyngeal system development [IGI, IMP]
- positive regulation of branching involved in ureteric bud morphogenesis [IMP]
- positive regulation of mesenchymal cell proliferation involved in ureter development [IGI]
- positive regulation of secondary heart field cardioblast proliferation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of ureteric bud formation [IMP]
- protein localization to nucleus [ISO]
- regulation of branch elongation involved in ureteric bud branching [IMP]
- regulation of epithelial cell proliferation [IMP]
- regulation of gene expression [IGI]
- regulation of neuron differentiation [IGI, IMP]
- regulation of protein localization [IGI]
- regulation of satellite cell proliferation [IDA]
- regulation of skeletal muscle cell differentiation [IDA]
- regulation of synaptic growth at neuromuscular junction [IGI]
- regulation of transcription, DNA-templated [IDA]
- renal system development [IGI]
- sensory perception of sound [IMP]
- skeletal muscle tissue development [IGI, IMP]
- skeletal system morphogenesis [IMP]
- thymus development [IGI, IMP]
- thyroid gland development [IMP]
- tongue development [IMP]
- transcription from RNA polymerase II promoter [ISO]
- trigeminal ganglion development [IMP]
- ureter smooth muscle cell differentiation [IMP]
- ureteric bud development [IGI, IMP]
Gene Ontology Molecular Function- DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IGI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IGI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
NEUROG1
Gene Ontology Biological Process
- cell fate commitment [IGI]
- inner ear morphogenesis [IMP]
- neurogenesis [IDA]
- neuron differentiation [IDA, IMP]
- positive regulation of exit from mitosis [IMP]
- positive regulation of neuron differentiation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of neuron differentiation [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear.
Inner ear neurogenesis depends upon the function of the proneural basic helix-loop-helix (bHLH) transcription factors NEUROG1 and NEUROD1. However, the transcriptional regulation of these factors is unknown. Here, using loss- and gain-of-function models, we show that EYA1 and SIX1 are crucial otic neuronal determination factors upstream of NEUROG1 and NEUROD1. Overexpression of both Eya1 and Six1 is sufficient to convert ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 10.
- figure 9.
Curated By
- BioGRID