FMR1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell body [IDA]
- cytoplasm [ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytoplasmic stress granule [ISO]
- dendrite [IDA, ISO]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- mRNA cap binding complex [ISO, ISS]
- membrane [ISO]
- microtubule [IDA]
- neuron projection [IDA]
- neuronal ribonucleoprotein granule [IDA, ISO]
- nucleus [IBA, ISO]
- polysome [IDA]
- synapse [IDA]
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation.
Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP), which represses and reversibly regulates the translation of a subset of mRNAs in dendrites. Protein synthesis can be rapidly stimulated by mGluR-induced and protein phosphatase 2a (PP2A)-mediated dephosphorylation of FMRP, which is coupled to the dissociation of FMRP and target mRNAs from miRNA-induced silencing complexes. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID