BAIT
RNF41
2210404G21Rik, 4930511A05Rik, 4933415P08Rik, D10Ertd722e, FLRF, Nrdp1
ring finger protein 41
GO Process (16)
GO Function (4)
GO Component (0)
Gene Ontology Biological Process
- extrinsic apoptotic signaling pathway [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- proteasomal protein catabolic process [ISO]
- protein autoubiquitination [ISO]
- protein polyubiquitination [IDA, ISO]
- protein ubiquitination [IDA]
- regulation of MAPK cascade [ISO]
- regulation of establishment of cell polarity [IDA]
- regulation of gene expression [IDA]
- regulation of lymphocyte differentiation [IDA]
- regulation of myeloid cell differentiation [IDA]
- regulation of protein kinase B signaling [ISO]
- regulation of reactive oxygen species metabolic process [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
RTN4
1110020G17Rik, AA407876, AA409940, AA960376, ASY, C130026I10Rik, NOGO, NSP-CL, NgA, Nogo-A, Nogo-B, Nogo-C, mKIAA0886, mKIAA4153, RP23-176O5.4
reticulon 4
GO Process (19)
GO Function (3)
GO Component (13)
Gene Ontology Biological Process
- angiogenesis [IMP]
- axonal fasciculation [IMP, ISO]
- cardiac epithelial to mesenchymal transition [IMP]
- cerebral cortex radial glia guided migration [IMP]
- endoplasmic reticulum tubular network organization [ISO]
- negative regulation of axon extension [IMP, ISO, ISS]
- negative regulation of axonogenesis [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of neuron projection development [ISO]
- negative regulation of neuron projection regeneration [ISO]
- nervous system development [IDA]
- positive regulation of dopamine secretion [ISO]
- positive regulation of glial cell differentiation [ISO]
- regulation of axon regeneration [ISO]
- regulation of branching morphogenesis of a nerve [IMP, ISO]
- regulation of cell migration [ISO]
- regulation of nervous system development [IMP]
- regulation of sensory perception of pain [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell projection [IDA]
- cytoplasm [ISO]
- endoplasmic reticulum [IDA, ISO]
- extracellular vesicular exosome [ISO]
- integral component of endoplasmic reticulum membrane [ISO, ISS]
- intracellular [ISO]
- myelin sheath [ISO]
- neuron projection [ISO]
- neuronal cell body [IDA, ISO]
- neuronal postsynaptic density [IDA]
- nuclear envelope [ISO, ISS]
- plasma membrane [ISO]
- protein complex [ISO]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures.
BACKGROUND: Identification of the genes underlying psychiatric illness remains a thorny problem. Previously, Quantitative Trait Loci (QTL) for anxiety-like behaviors and beta-carboline-induced seizure vulnerability have been mapped to the distal portion of mouse chromosome 10, with crosses of A/J and C57BL6 mice. METHODS: An interval specific congenic strain for this chromosomal 10 region facilitated the genetic dissection of novelty-induced exploratory ... [more]
Biol. Psychiatry Mar. 01, 2009; 65(5);425-31 [Pubmed: 18986647]
Throughput
- Low Throughput
Curated By
- BioGRID