BAIT
TBX1
T-box 1
GO Process (64)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- angiogenesis [IMP]
- anterior/posterior pattern specification [IGI, IMP]
- aorta morphogenesis [IGI, IMP]
- artery morphogenesis [IGI, IMP]
- blood vessel development [IGI, IMP]
- blood vessel morphogenesis [IMP]
- blood vessel remodeling [IGI]
- cell fate specification [IGI, IMP]
- cell proliferation [IDA]
- cellular response to fibroblast growth factor stimulus [IMP]
- cochlea morphogenesis [IGI, IMP]
- coronary artery morphogenesis [IMP, TAS]
- determination of left/right symmetry [IMP]
- ear morphogenesis [IMP]
- embryonic cranial skeleton morphogenesis [IMP]
- embryonic viscerocranium morphogenesis [ISO, ISS]
- enamel mineralization [IMP]
- epithelial cell differentiation [IMP]
- face morphogenesis [IMP]
- heart development [IGI, IMP, ISO, ISS]
- heart morphogenesis [IMP]
- inner ear morphogenesis [IMP]
- lymph vessel development [IMP]
- mesenchymal cell apoptotic process [IMP]
- mesoderm development [IMP]
- middle ear morphogenesis [IMP]
- muscle cell fate commitment [IMP]
- muscle organ development [IMP]
- muscle organ morphogenesis [IGI]
- muscle tissue morphogenesis [IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of mesenchymal cell apoptotic process [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neural crest cell migration [IMP]
- odontogenesis of dentin-containing tooth [IMP]
- otic vesicle morphogenesis [IMP]
- outer ear morphogenesis [IMP]
- outflow tract morphogenesis [IGI, IMP]
- outflow tract septum morphogenesis [IMP]
- parathyroid gland development [ISO, ISS]
- pattern specification process [IGI, IMP]
- patterning of blood vessels [TAS]
- pharyngeal system development [IGI, IMP, ISO, ISS]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of secondary heart field cardioblast proliferation [IDA]
- positive regulation of tongue muscle cell differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of organ morphogenesis [IGI, IMP]
- regulation of transcription from RNA polymerase II promoter [IGI]
- retinoic acid receptor signaling pathway [IMP]
- semicircular canal morphogenesis [IGI]
- sensory perception of sound [IMP]
- social behavior [IMP]
- soft palate development [ISO, ISS]
- thymus development [IMP, ISO, ISS]
- thyroid gland development [IGI, IMP]
- tongue morphogenesis [IMP]
- transcription from RNA polymerase II promoter [IDA]
- vagus nerve morphogenesis [IMP]
Gene Ontology Molecular Function- DNA binding [ISO]
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- sequence-specific DNA binding [ISO, ISS]
- DNA binding [ISO]
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- sequence-specific DNA binding [ISO, ISS]
Mus musculus
PREY
WNT5A
8030457G12Rik, Wnt-5a, RP24-345B5.1
wingless-type MMTV integration site family, member 5A
GO Process (126)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- JNK cascade [IDA]
- Wnt signaling pathway [IGI, ISO]
- Wnt signaling pathway, calcium modulating pathway [IDA, IMP, ISO]
- Wnt signaling pathway, planar cell polarity pathway [IDA, IGI, IMP, ISO]
- activation of JUN kinase activity [ISO]
- activation of MAPK activity [ISO]
- activation of protein kinase B activity [ISO]
- ameboidal-type cell migration [IMP]
- anterior/posterior axis specification, embryo [IDA]
- anterior/posterior pattern specification [IMP]
- axis elongation [IMP]
- axon guidance [IDA]
- canonical Wnt signaling pathway [IDA, IGI, IMP]
- cell fate commitment [IBA]
- cell migration [IGI, IMP]
- cell-cell signaling [TAS]
- cellular protein localization [IMP, ISO]
- cellular response to molecule of bacterial origin [IDA]
- cervix development [IMP]
- cochlea morphogenesis [IGI, IMP]
- convergent extension [IMP]
- convergent extension involved in organogenesis [IGI]
- determination of left/right symmetry [IMP]
- development of primary male sexual characteristics [IMP]
- digestive tract morphogenesis [IMP]
- dopaminergic neuron differentiation [IGI, IMP]
- embryo development [IMP]
- embryonic digit morphogenesis [IMP]
- embryonic limb morphogenesis [IMP]
- embryonic skeletal system development [ISO]
- epithelial cell proliferation involved in mammary gland duct elongation [IDA]
- establishment of planar polarity [IMP]
- face development [ISO]
- genitalia development [ISO]
- heart looping [IGI]
- hematopoietic stem cell proliferation [IDA, IMP, ISO]
- hindgut morphogenesis [IMP]
- hypophysis morphogenesis [IMP]
- inner ear morphogenesis [IDA, IMP]
- lateral sprouting involved in mammary gland duct morphogenesis [IDA]
- limb morphogenesis [IMP]
- lung development [IMP]
- male gonad development [IMP]
- mammary gland branching involved in thelarche [IDA]
- mesenchymal-epithelial cell signaling [IMP]
- midgut development [IMP]
- morphogenesis of an epithelium [IMP]
- negative chemotaxis [IGI]
- negative regulation of BMP signaling pathway [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of axon extension involved in axon guidance [IGI]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- negative regulation of epithelial cell proliferation [IDA, IMP]
- negative regulation of fat cell differentiation [ISO]
- negative regulation of fibroblast growth factor receptor signaling pathway [IMP]
- negative regulation of mesenchymal cell proliferation [ISO]
- negative regulation of prostatic bud formation [IMP]
- negative regulation of synapse assembly [IDA]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [IGI]
- neural tube development [IGI]
- neuron projection morphogenesis [IDA]
- non-canonical Wnt signaling pathway [IDA]
- non-canonical Wnt signaling pathway via JNK cascade [IMP]
- olfactory bulb interneuron development [IMP]
- organ morphogenesis [TAS]
- palate development [ISO]
- pericardium morphogenesis [IGI]
- planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [IMP]
- planar cell polarity pathway involved in cardiac right atrium morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IMP]
- planar cell polarity pathway involved in outflow tract morphogenesis [IMP]
- planar cell polarity pathway involved in pericardium morphogenesis [IMP]
- planar cell polarity pathway involved in ventricular septum morphogenesis [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of JUN kinase activity [IDA, IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of T cell chemotaxis [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cGMP metabolic process [ISO]
- positive regulation of cartilage development [IDA, IMP]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of cell-cell adhesion [ISO]
- positive regulation of cell-cell adhesion mediated by cadherin [IDA]
- positive regulation of chemokine biosynthetic process [ISO]
- positive regulation of cytokine production [IDA]
- positive regulation of cytokine secretion involved in immune response [ISO]
- positive regulation of endocytosis [IDA]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-1 beta secretion [IDA, ISO]
- positive regulation of interleukin-6 production [IDA, ISO]
- positive regulation of interleukin-8 secretion [IDA]
- positive regulation of macrophage activation [ISO]
- positive regulation of macrophage cytokine production [ISO]
- positive regulation of meiosis [IGI]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of neuron projection development [IDA]
- positive regulation of ossification [ISO]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of peptidyl-threonine phosphorylation [IGI]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein kinase C signaling [ISO]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of response to cytokine stimulus [ISO]
- positive regulation of thymocyte apoptotic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of type I interferon-mediated signaling pathway [ISO]
- post-anal tail morphogenesis [IGI, IMP]
- primitive streak formation [IGI]
- protein phosphorylation [IGI]
- regulation of branching involved in mammary gland duct morphogenesis [IDA, IGI]
- regulation of protein localization [IDA]
- signal transduction [TAS]
- somitogenesis [IGI]
- tube closure [IMP]
- type B pancreatic cell development [IMP]
- urinary bladder development [IMP]
- uterus development [IMP]
- vagina development [IMP]
- wound healing [ISO]
Gene Ontology Molecular Function- cytokine activity [IDA]
- frizzled binding [IPI, ISO]
- frizzled-2 binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- receptor binding [IPI, TAS]
- receptor tyrosine kinase-like orphan receptor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- cytokine activity [IDA]
- frizzled binding [IPI, ISO]
- frizzled-2 binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- receptor binding [IPI, TAS]
- receptor tyrosine kinase-like orphan receptor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a.
Mutations of the Wnt5a gene, encoding a ligand of the non-canonical Wnt pathway, and the Ror2 gene, encoding its receptor, have been found in patients with cardiac outflow tract defects. We found that Wnt5a is expressed in the second heart field (SHF), a population of cardiac progenitor cells destined to populate the cardiac outflow tract and the right ventricle. Because ... [more]
PLoS Genet. Mar. 01, 2012; 8(3);e1002571 [Pubmed: 22438823]
Throughput
- Low Throughput
Additional Notes
- figure 2, table 1.
- figure 3.
- figure 4.
Curated By
- BioGRID