SMARCD1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TBX1
Gene Ontology Biological Process
- angiogenesis [IMP]
- anterior/posterior pattern specification [IGI, IMP]
- aorta morphogenesis [IGI, IMP]
- artery morphogenesis [IGI, IMP]
- blood vessel development [IGI, IMP]
- blood vessel morphogenesis [IMP]
- blood vessel remodeling [IGI]
- cell fate specification [IGI, IMP]
- cell proliferation [IDA]
- cellular response to fibroblast growth factor stimulus [IMP]
- cochlea morphogenesis [IGI, IMP]
- coronary artery morphogenesis [IMP, TAS]
- determination of left/right symmetry [IMP]
- ear morphogenesis [IMP]
- embryonic cranial skeleton morphogenesis [IMP]
- embryonic viscerocranium morphogenesis [ISO, ISS]
- enamel mineralization [IMP]
- epithelial cell differentiation [IMP]
- face morphogenesis [IMP]
- heart development [IGI, IMP, ISO, ISS]
- heart morphogenesis [IMP]
- inner ear morphogenesis [IMP]
- lymph vessel development [IMP]
- mesenchymal cell apoptotic process [IMP]
- mesoderm development [IMP]
- middle ear morphogenesis [IMP]
- muscle cell fate commitment [IMP]
- muscle organ development [IMP]
- muscle organ morphogenesis [IGI]
- muscle tissue morphogenesis [IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of mesenchymal cell apoptotic process [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neural crest cell migration [IMP]
- odontogenesis of dentin-containing tooth [IMP]
- otic vesicle morphogenesis [IMP]
- outer ear morphogenesis [IMP]
- outflow tract morphogenesis [IGI, IMP]
- outflow tract septum morphogenesis [IMP]
- parathyroid gland development [ISO, ISS]
- pattern specification process [IGI, IMP]
- patterning of blood vessels [TAS]
- pharyngeal system development [IGI, IMP, ISO, ISS]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of secondary heart field cardioblast proliferation [IDA]
- positive regulation of tongue muscle cell differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of organ morphogenesis [IGI, IMP]
- regulation of transcription from RNA polymerase II promoter [IGI]
- retinoic acid receptor signaling pathway [IMP]
- semicircular canal morphogenesis [IGI]
- sensory perception of sound [IMP]
- social behavior [IMP]
- soft palate development [ISO, ISS]
- thymus development [IMP, ISO, ISS]
- thyroid gland development [IGI, IMP]
- tongue morphogenesis [IMP]
- transcription from RNA polymerase II promoter [IDA]
- vagus nerve morphogenesis [IMP]
Gene Ontology Molecular Function- DNA binding [ISO]
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- sequence-specific DNA binding [ISO, ISS]
- DNA binding [ISO]
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- sequence-specific DNA binding [ISO, ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a.
Mutations of the Wnt5a gene, encoding a ligand of the non-canonical Wnt pathway, and the Ror2 gene, encoding its receptor, have been found in patients with cardiac outflow tract defects. We found that Wnt5a is expressed in the second heart field (SHF), a population of cardiac progenitor cells destined to populate the cardiac outflow tract and the right ventricle. Because ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 9A.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TBX1 SMARCD1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 669481 |
Curated By
- BioGRID