BAIT

PSMA2

proteasome (prosome, macropain) subunit, alpha type 2
GO Process (1)
GO Function (0)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Rattus norvegicus
PREY

HOMER3

Vesl-3
homer homolog 3 (Drosophila)
Rattus norvegicus

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Proteasomal degradation of the metabotropic glutamate receptor 1α is mediated by Homer-3 via the proteasomal S8 ATPase: Signal transduction and synaptic transmission.

Rezvani K, Baalman K, Teng Y, Mee MP, Dawson SP, Wang H, De Biasi M, Mayer RJ

J. Neurochem. (2012) 122, 24-37. ABSTRACT: The metabotropic glutamate receptors (mGluRs) fine-tune the efficacy of synaptic transmission. This unique feature makes mGluRs potential targets for the treatment of various CNS disorders. There is ample evidence to show that the ubiquitin proteasome system mediates changes in synaptic strength leading to multiple forms of synaptic plasticity. The present study describes a novel ... [more]

J. Neurochem. Jul. 01, 2012; 122(1);24-37 [Pubmed: 22486777]

Throughput

  • Low Throughput

Curated By

  • BioGRID