Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage.

Olsen BB, Wang SY, Svenstrup TH, Chen BP, Guerra B

The DNA-dependent protein kinase (DNA-PK) is a nuclear complex composed of a large catalytic subunit (DNA-PKcs) and a heterodimeric DNA-targeting subunit Ku. DNA-PK is a major component of the non-homologous end-joining (NHEJ) repair mechanism, which is activated in the presence of DNA double-strand breaks induced by ionizing radiation, reactive oxygen species and radiomimetic drugs. We have recently reported that down-regulation ... [more]

BMC Mol. Biol. Mar. 13, 2012; 13(0);7 [Pubmed: 22404984]

Throughput

Low Throughput

Additional Notes

figure S3.

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
HIST1H3A PRKDC	Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.	Liu X (2018)	High	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

PRKDC

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA-dependent protein kinase activity [IDA]poly(A) RNA binding [IDA]protein binding [IPI]protein kinase activity [TAS]protein serine/threonine kinase activity [IDA]transcription factor binding [IPI]

Gene Ontology Cellular Component

HIST1H3A