BAIT
JAK3
fae, wil
Janus kinase 3
GO Process (37)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- T cell homeostasis [IMP]
- cell migration [IBA]
- cytokine-mediated signaling pathway [IDA, ISO]
- enzyme linked receptor protein signaling pathway [IDA]
- erythrocyte differentiation [IBA]
- inflammatory response [IBA]
- innate immune response [IBA]
- interleukin-4-mediated signaling pathway [ISO]
- intracellular signal transduction [IDA]
- lymph node development [TAS]
- negative regulation of FasL biosynthetic process [IMP]
- negative regulation of T cell activation [IMP]
- negative regulation of T-helper 1 cell differentiation [IMP]
- negative regulation of dendritic cell cytokine production [IMP]
- negative regulation of interleukin-10 production [IMP]
- negative regulation of interleukin-12 production [IMP]
- negative regulation of thymocyte apoptotic process [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of T cell proliferation [IBA, ISO]
- positive regulation of activated T cell proliferation [ISO]
- positive regulation of calcium ion transport [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of dendritic cell apoptotic process [IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- positive regulation of immune response [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein autophosphorylation [ISO]
- regulation of T cell apoptotic process [IMP]
- response to interleukin-15 [TAS]
- response to interleukin-2 [TAS]
- response to interleukin-4 [ISO, TAS]
- response to interleukin-9 [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- tyrosine phosphorylation of STAT protein [IBA]
- tyrosine phosphorylation of Stat5 protein [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
STAT3
1110034C02Rik, AW109958, Aprf, RP23-279L23.5
signal transducer and activator of transcription 3
GO Process (35)
GO Function (13)
GO Component (7)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISO]
- astrocyte differentiation [IMP]
- cell proliferation [IDA]
- cellular response to hormone stimulus [ISO]
- cytokine-mediated signaling pathway [NAS]
- eating behavior [IMP]
- eye photoreceptor cell differentiation [IMP]
- glucose homeostasis [IMP]
- growth hormone receptor signaling pathway [ISO]
- interleukin-6-mediated signaling pathway [ISO]
- intracellular receptor signaling pathway [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of glycolytic process [IMP]
- negative regulation of hydrogen peroxide biosynthetic process [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of neuron migration [IGI]
- phosphorylation [IDA]
- positive regulation of ATP biosynthetic process [ISO]
- positive regulation of Notch signaling pathway [IMP]
- positive regulation of growth factor dependent skeletal muscle satellite cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein import into nucleus [ISO]
- radial glial cell differentiation [IMP]
- regulation of mitochondrial membrane permeability [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of transcription, DNA-templated [ISO, NAS]
- response to cytokine [ISO]
- response to estradiol [ISO]
- sexual reproduction [IMP]
- stem cell maintenance [IMP]
- temperature homeostasis [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
JAK-STAT and JAK-PI3K-mTORC1 pathways regulate telomerase transcriptionally and posttranslationally in ATL cells.
Adult T-cell leukemia (ATL) is a heterogeneous tumor that is resistant to chemotherapy. Telomerase activity plays a critical role in tumorigenesis and is associated with the prognosis of ATL patients. Interleukin (IL)-2 commonly promotes tumor growth in chronic ATL cells. The signaling pathways involved in IL-2-regulated telomerase activation were studied in ATL cells derived from chronic ATL patients. IL-2 challenge ... [more]
Mol. Cancer Ther. May. 01, 2012; 11(5);1112-21 [Pubmed: 22402124]
Throughput
- Low Throughput
Additional Notes
- figure 2C.only in HUT102 cells.
Curated By
- BioGRID