HCK
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- cell adhesion [TAS]
- cell differentiation [IBA]
- cellular response to peptide hormone stimulus [IBA]
- cytokine-mediated signaling pathway [TAS]
- innate immune response [IBA, TAS]
- innate immune response-activating signal transduction [TAS]
- integrin-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte degranulation [TAS]
- leukocyte migration involved in immune response [TAS]
- lipopolysaccharide-mediated signaling pathway [TAS]
- mesoderm development [TAS]
- negative regulation of apoptotic process [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of actin cytoskeleton reorganization [IDA, IMP]
- positive regulation of actin filament polymerization [TAS]
- positive regulation of cell proliferation [IMP]
- protein autophosphorylation [IMP]
- protein phosphorylation [TAS]
- regulation of cell shape [IMP]
- regulation of defense response to virus by virus [TAS]
- regulation of inflammatory response [TAS]
- regulation of phagocytosis [IMP]
- regulation of podosome assembly [IDA]
- regulation of sequence-specific DNA binding transcription factor activity [IMP]
- respiratory burst after phagocytosis [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KHDRBS1
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [ISS]
- cell cycle arrest [TAS]
- cell proliferation [TAS]
- cell surface receptor signaling pathway [IDA]
- mRNA processing [TAS]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of RNA export from nucleus [IDA]
- positive regulation of translational initiation [IDA]
- regulation of RNA export from nucleus [ISS]
- regulation of protein stability [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Comprehensive Analysis of Interactions between the Src-Associated Protein in Mitosis of 68 kDa and the Human Src-Homology 3 Proteome.
The protein Sam68 is involved in many cellular processes such as cell-cycle regulation, RNA metabolism, or signal transduction. Sam68 comprises a central RNA-binding domain flanked by unstructured tails containing docking sites for signalling proteins including seven proline-rich sequences (denoted P0 to P6) as potential SH3-domain binding motifs. To comprehensively assess Sam68-SH3-interactions, we applied a phage-display screening of a library containing ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KHDRBS1 HCK | FRET FRET An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins. | Low | - | BioGRID | - | |
| KHDRBS1 HCK | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | - |
Curated By
- BioGRID