TLE1
Gene Ontology Biological Process
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of gene expression [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
FOXG1
Gene Ontology Biological Process
- aging [IEP]
- axon midline choice point recognition [ISO]
- brain development [IEP]
- cell morphogenesis involved in neuron differentiation [ISO]
- central nervous system neuron development [ISO]
- cerebral cortex development [ISO]
- dorsal/ventral pattern formation [ISO]
- forebrain development [ISO]
- inner ear morphogenesis [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neurogenesis [ISO]
- neuron fate determination [ISO]
- positive regulation of cell cycle [ISO]
- positive regulation of neuroblast proliferation [ISO]
- positive regulation of neuron differentiation [ISO]
- pyramidal neuron migration [ISO]
- regulation of cell cycle [ISO]
- regulation of gene expression [ISO]
- regulation of mitotic cell cycle [ISO]
- regulation of neural precursor cell proliferation [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Transducin-like enhancer of Split-1 (TLE1) combines with Forkhead box protein G1 (FoxG1) to promote neuronal survival.
Transducin-like enhancer of split-1 (TLE1) plays a critical role in the regulation of neurogenesis by inhibiting the differentiation of neural progenitor cells into neurons. Although TLE1 is also expressed highly in the postnatal brain and through adulthood, its role in postmitotic neurons is not clear. Using cultures of cerebellar granule neurons, we show that expression of TLE1 is reduced in ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 6. from HEK293T cells.
- figure 7A.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FOXG1 TLE1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 670497 |
Curated By
- BioGRID