ARAP3
Gene Ontology Biological Process
- cytoskeleton organization [TAS]
- negative regulation of Rho protein signal transduction [ISS]
- negative regulation of cell migration [ISS]
- regulation of cell shape [ISS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
ASAP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors.
CIN85 is a multidomain adaptor protein involved in Cbl-mediated down-regulation of epidermal growth factor (EGF) receptors. CIN85 src homology 3 domains specifically bind to a proline-arginine (PxxxPR) motif in Cbl, and this association seems to be important for EGF receptor endocytosis. Here, we report identification of novel CIN85 effectors, all containing one or more PxxxPR motifs, that are indispensable for ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID