BAIT

CASP10

ALPS2, FLICE2, MCH4
caspase 10, apoptosis-related cysteine peptidase
Homo sapiens
PREY

ORT1

ARG11, L000003289, YOR130C
Ornithine transporter of the mitochondrial inner membrane; exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

The protein Factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling.

Lisa-Santamaria P, Jimenez A, Revuelta JL

The heterologous expression of human caspase-10 in S. cerevisiae induces a lethal phenotype, which includes some hallmarks of apoptosis and autophagy, alterations in the intra-S checkpoint, and cell death. In order to determine the cellular processes and pathways that are responsible of the caspase-10-induced cell death we have designed a loss-of-function screening system to identify genes that are essential for ... [more]

J. Biol. Chem Jul. 10, 2012; 0(0); [Pubmed: 22782902]

Throughput

  • High Throughput

Ontology Terms

  • phenotype: viability (APO:0000111)

Additional Notes

  • mutants rescue the cell death induced by expression of Caspase 10 in S. cerevisiae

Curated By

  • BioGRID