DNM1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DYRK1A
Gene Ontology Biological Process
- circadian rhythm [ISO, ISS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- negative regulation of mRNA splicing, via spliceosome [ISO]
- nervous system development [TAS]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [ISO]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of protein deacetylation [ISO]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of alternative mRNA splicing, via spliceosome [IDA]
- regulation of endocytosis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Mnb/Dyrk1A phosphorylation regulates the interaction of dynamin 1 with SH3 domain-containing proteins.
Mnb/Dyrk1A is a proline-directed serine/threonine kinase implicated in Down's syndrome. Mnb/Dyrk1A was shown to phosphorylate dynamin 1 and alter its interactions with several SH3 domain-containing endocytic accessory proteins. To determine the mechanism of regulation, we mapped the Mnb/Dyrk1A phosphorylation sites in dynamin 1. Using a combination of deletion mutants and synthetic peptides, three potential Mnb/Dyrk1A phosphorylation sites (S778, S795, and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID