PPP3CB
Gene Ontology Biological Process
- T cell differentiation [ISO]
- T cell homeostasis [ISO]
- calcineurin-NFAT signaling cascade [ISO]
- calcium ion-dependent exocytosis [ISO, ISS]
- cellular response to drug [ISO, ISS]
- dephosphorylation [ISO]
- heart development [ISO]
- locomotion involved in locomotory behavior [ISO]
- muscle cell cellular homeostasis [IEP]
- negative regulation of T cell mediated cytotoxicity [ISO]
- positive regulation of NFAT protein import into nucleus [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein dephosphorylation [IDA, ISO]
- protein phosphorylation [ISO, ISS]
- regulation of gene expression [ISO]
- regulation of insulin secretion [IDA]
- response to amphetamine [IEP]
- response to cytokine [ISO]
- social behavior [ISO]
Gene Ontology Molecular Function- calcium ion binding [ISO, ISS]
- calcium-dependent protein serine/threonine phosphatase activity [IDA]
- calmodulin binding [IDA, ISO]
- calmodulin-dependent protein phosphatase activity [ISO, ISS]
- drug binding [ISO, ISS]
- enzyme binding [ISO, ISS]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [IDA]
- protein phosphatase 2B binding [ISO, ISS]
- protein serine/threonine phosphatase activity [ISO, TAS]
- calcium ion binding [ISO, ISS]
- calcium-dependent protein serine/threonine phosphatase activity [IDA]
- calmodulin binding [IDA, ISO]
- calmodulin-dependent protein phosphatase activity [ISO, ISS]
- drug binding [ISO, ISS]
- enzyme binding [ISO, ISS]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [IDA]
- protein phosphatase 2B binding [ISO, ISS]
- protein serine/threonine phosphatase activity [ISO, TAS]
Gene Ontology Cellular Component
AMPH
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Dephosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Amphiphysin I is associated with coated endocytic intermediates and undergoes stimulation-dependent dephosphorylation in nerve terminals.
Amphiphysin I is an abundant presynaptic protein that interacts via its COOH-terminal src homology 3 (SH3) domain with the GTPase dynamin I and the inositol-5-phosphatase synaptojanin. Both dynamin I and synaptojanin I have a putative role in synaptic vesicle recycling and undergo rapid dephosphorylation in rat brain synaptosomes stimulated to secrete by a depolarizing stimulus. We show here that amphiphysin ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID