GRB2
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- aging [IPI]
- anatomical structure formation involved in morphogenesis [ISO]
- branching involved in labyrinthine layer morphogenesis [ISO]
- cell differentiation [ISO]
- cellular response to ionizing radiation [ISO]
- fibroblast growth factor receptor signaling pathway [ISO]
- insulin receptor signaling pathway [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of signal transduction [ISO]
- protein heterooligomerization [IDA]
- receptor internalization [ISO]
- regulation of MAPK cascade [ISO]
- signal transduction in response to DNA damage [ISO]
Gene Ontology Molecular Function- SH3 domain binding [ISO, ISS]
- SH3/SH2 adaptor activity [ISO]
- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI, ISO, ISS]
- identical protein binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- SH3 domain binding [ISO, ISS]
- SH3/SH2 adaptor activity [ISO]
- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI, ISO, ISS]
- identical protein binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
Gene Ontology Cellular Component
DNM1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Inhibition of receptor-mediated endocytosis by the amphiphysin SH3 domain.
Receptor-mediated endocytosis appears to require the GTP-binding protein dynamin, but the process by which dynamin is recruited to clathrin-coated pits remains unclear. Dynamin contains several proline-rich clusters that bind to Src homology 3 (SH3) domains, which are short modules found in many signalling proteins and which mediate protein-protein interactions. Amphiphysin, a protein that is highly expressed in the brain, interacts ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID