BAIT
RUNX1
AML1, CBF-alpha-2, Cbfa2, Pebp2a2, Pebpa2b
runt related transcription factor 1
GO Process (25)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- behavioral response to pain [IMP]
- cellular response to transforming growth factor beta stimulus [IDA]
- central nervous system development [IMP]
- definitive hemopoiesis [IMP]
- embryonic hemopoiesis [IMP]
- hair follicle morphogenesis [IMP]
- hemopoiesis [ISO, TAS]
- in utero embryonic development [IMP]
- liver development [IMP]
- myeloid cell differentiation [ISO]
- myeloid progenitor cell differentiation [IMP]
- negative regulation of granulocyte differentiation [ISO]
- neuron development [IMP]
- neuron differentiation [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of granulocyte differentiation [ISO]
- positive regulation of progesterone secretion [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of hair follicle cell proliferation [IMP]
- regulation of signal transduction [IMP]
- regulation of transcription, DNA-templated [IDA]
- response to retinoic acid [IDA]
- skeletal system development [IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- calcium ion binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- regulatory region DNA binding [ISO]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- calcium ion binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- regulatory region DNA binding [ISO]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
POLD3
2410142G14Rik, C85233, P66, P68
polymerase (DNA-directed), delta 3, accessory subunit
GO Process (2)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.
Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study we show that Bmi1, a core component of Polycomb Repressive Complex 1 (PRC1), binds directly to the Runx1/CBFβ transcription factor complex. Genome-wide studies in megakaryocytic cells demonstrate significant chromatin occupancy overlap ... [more]
Mol. Cell Feb. 10, 2012; 45(3);330-43 [Pubmed: 22325351]
Throughput
- High Throughput
Additional Notes
- figure 1A, table S1.
Curated By
- BioGRID