RUNX1
Gene Ontology Biological Process
- behavioral response to pain [IMP]
- cellular response to transforming growth factor beta stimulus [IDA]
- central nervous system development [IMP]
- definitive hemopoiesis [IMP]
- embryonic hemopoiesis [IMP]
- hair follicle morphogenesis [IMP]
- hemopoiesis [ISO, TAS]
- in utero embryonic development [IMP]
- liver development [IMP]
- myeloid cell differentiation [ISO]
- myeloid progenitor cell differentiation [IMP]
- negative regulation of granulocyte differentiation [ISO]
- neuron development [IMP]
- neuron differentiation [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of granulocyte differentiation [ISO]
- positive regulation of progesterone secretion [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of hair follicle cell proliferation [IMP]
- regulation of signal transduction [IMP]
- regulation of transcription, DNA-templated [IDA]
- response to retinoic acid [IDA]
- skeletal system development [IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- calcium ion binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- regulatory region DNA binding [ISO]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- calcium ion binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- regulatory region DNA binding [ISO]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
RNF2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.
Polycomb repressive complexes (PRCs) play key roles in developmental epigenetic regulation. Yet the mechanisms that target PRCs to specific loci in mammalian cells remain incompletely understood. In this study we show that Bmi1, a core component of Polycomb Repressive Complex 1 (PRC1), binds directly to the Runx1/CBFβ transcription factor complex. Genome-wide studies in megakaryocytic cells demonstrate significant chromatin occupancy overlap ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 1B.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RNF2 RUNX1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 671377 |
Curated By
- BioGRID