CBX1
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KLF11
Gene Ontology Biological Process
- negative regulation of cell proliferation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of apoptotic process [IDA]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IDA]
- transcription from RNA polymerase II promoter [TAS]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krueppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases.
Heterochromatin protein 1 (HP1) proteins are "gatekeepers" of epigenetic gene silencing that is mediated by lysine 9 of histone H3 methylation (H3K9me). Current knowledge supports a paradigm whereby HP1 proteins achieve repression by binding to H3K9me marks and interacting to H3K9 histone methyltransferases (HMTs), such as SUV39H1, which methylate this residue on adjacent nucleosomes thereby compacting chromatin and silencing gene ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 1B.
- figure 1C,D. mapping the interaction region on Klf11.
Curated By
- BioGRID