BAIT

SEC3

SPAC17G8.12, SPAC17G8.12
exocyst complex subunit Sec3
GO Process (5)
GO Function (1)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

EXO70

SPBC582.02, SPBC106.20
exocyst complex subunit Exo70
GO Process (3)
GO Function (1)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Fission yeast sec3 and exo70 are transported on actin cables and localize the exocyst complex to cell poles.

Bendezu FO, Vincenzetti V, Martin SG

The exocyst complex is essential for many exocytic events, by tethering vesicles at the plasma membrane for fusion. In fission yeast, polarized exocytosis for growth relies on the combined action of the exocyst at cell poles and myosin-driven transport along actin cables. We report here the identification of fission yeast Schizosaccharomyces pombe Sec3 protein, which we identified through sequence homology ... [more]

PLoS ONE Jul. 07, 2012; 7(6);e40248 [Pubmed: 22768263]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)
  • phenotype: protein/peptide accumulation (APO:0000149)

Additional Notes

  • double mutants show lethality and aberrant localization of the exocyst

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
SEC3 EXO70
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
734681

Curated By

  • BioGRID