An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

Zhang P, Lee H, Brunzelle JS, Couture JF

In mammals, the SET1 family of lysine methyltransferases (KMTs), which includes MLL1-5, SET1A and SET1B, catalyzes the methylation of lysine-4 (Lys-4) on histone H3. Recent reports have demonstrated that a three-subunit complex composed of WD-repeat protein-5 (WDR5), retinoblastoma-binding protein-5 (RbBP5) and absent, small, homeotic disks-2-like (ASH2L) stimulates the methyltransferase activity of MLL1. On the basis of studies showing that this ... [more]

Nucleic Acids Res. May. 01, 2012; 40(9);4237-46 [Pubmed: 22266653]

Throughput

Low Throughput

Additional Notes

figure 4.

Curated By

BioGRID

Interaction Summary

SETD1A

Gene Ontology Biological Process

Gene Ontology Molecular Function

histone methyltransferase activity (H3-K4 specific) [IDA]protein binding [IPI]

Gene Ontology Cellular Component

HIST2H3C