BAIT
PPB1
SPBC1346.01c, SPBP4H10.04
calcium-dependent serine/threonine protein phosphatase calcineurin A, catalytic subunit Ppb1
GO Process (10)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- calcium-mediated signaling [IMP]
- cellular chloride ion homeostasis [IMP]
- cellular response to salt stress [IMP]
- cytosolic calcium ion homeostasis [IMP]
- fungal-type cell wall organization or biogenesis [IGI]
- negative regulation of calcium ion transport into cytosol [IMP]
- protein dephosphorylation [IC]
- regulation of conjugation with cellular fusion [IMP]
- regulation of establishment or maintenance of cell polarity regulating cell shape [IMP]
- regulation of mitotic cytokinesis [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
BGS1
cps1, drc1, SPBC19G7.05c
1,3-beta-glucan synthase catalytic subunit Bgs1
GO Process (6)
GO Function (0)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Zinc finger protein Prz1 regulates Ca2+ but not Cl- homeostasis in fission yeast. Identification of distinct branches of calcineurin signaling pathway in fission yeast.
Calcineurin is an important mediator that connects the Ca(2+)-dependent signaling to various cellular responses in a wide variety of cell types and organisms. In budding yeast, activated calcineurin exerts its function mainly by regulating the Crz1p/Tcn1 transcription factor. Here, we cloned the fission yeast prz1(+) gene, which encodes a zinc finger transcription factor highly homologous to Crz1/Tcn1. Similar to the ... [more]
J. Biol. Chem. May. 16, 2003; 278(20);18078-84 [Pubmed: 12637524]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID