BHLHE40
Gene Ontology Biological Process
- circadian regulation of gene expression [IDA]
- entrainment of circadian clock by photoperiod [ISS]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- regulation of transcription, DNA-templated [NAS]
- transcription from RNA polymerase II promoter [IDA, ISS]
Gene Ontology Molecular Function- E-box binding [IDA]
- MRF binding [ISS]
- RNA polymerase II activating transcription factor binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IDA]
- bHLH transcription factor binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription corepressor activity [IDA]
- E-box binding [IDA]
- MRF binding [ISS]
- RNA polymerase II activating transcription factor binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IDA]
- bHLH transcription factor binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription corepressor activity [IDA]
Gene Ontology Cellular Component
STAT3
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISS, TAS]
- astrocyte differentiation [ISS]
- cellular component movement [TAS]
- cellular response to hormone stimulus [IDA]
- cytokine-mediated signaling pathway [NAS]
- eating behavior [ISS]
- eye photoreceptor cell differentiation [ISS]
- glucose homeostasis [ISS]
- growth hormone receptor signaling pathway [IDA]
- interleukin-6-mediated signaling pathway [IDA]
- intracellular receptor signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphorylation [ISS]
- positive regulation of Notch signaling pathway [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- protein import into nucleus [IDA]
- radial glial cell differentiation [ISS]
- regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of transcription, DNA-templated [IDA]
- response to estradiol [IDA]
- sexual reproduction [ISS]
- signal transduction [TAS]
- temperature homeostasis [ISS]
Gene Ontology Molecular Function- DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [ISS]
- protein kinase binding [ISS]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [ISS]
- protein kinase binding [ISS]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets.
STRA13 is a pVHL-dependent bHLH transcription factor up-regulated on the mRNA level in multiple cancer cell lines and implicated recently in the regulation of immune cell homeostasis and autoimmunity. In searching for STRA13-interacting proteins with oncogenic potential by the yeast two-hybrid screening, we identified STAT3 beta as a STRA13-binding partner. We showed that STRA13 binds predominantly to phosphorylated (active) STAT3 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID