KDM6A
Gene Ontology Biological Process
Gene Ontology Cellular Component
TBX5
Gene Ontology Biological Process
- apoptotic nuclear changes [IDA]
- cardiac left ventricle formation [ISS]
- cell migration involved in coronary vasculogenesis [TAS]
- cell-cell signaling [IDA]
- embryonic forelimb morphogenesis [IMP]
- embryonic limb morphogenesis [IMP]
- forelimb morphogenesis [IMP]
- gene expression [TAS]
- heart development [IDA, IMP]
- negative regulation of cardiac muscle cell proliferation [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of epithelial to mesenchymal transition [TAS]
- pericardium development [IDA]
- positive regulation of cardioblast differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of execution phase of apoptosis [IC]
- transcription initiation from RNA polymerase II promoter [TAS]
- ventricular septum development [ISS]
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.
The removal of histone H3 lysine27 (H3K27) trimethylation mark is important for the robust induction of many cell type-specific genes during differentiation. Here we show that UTX, a H3K27 demethylase, acts as a critical switch to promote a cardiac-specific gene program. UTX-deficient ESCs failed to develop heart-like rhythmic contractions under a cardiac differentiation condition. UTX-deficient mice show severe defects in ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 4. The transcriptional activity of SRF, Tbx5, and Nkx2.5, alone or in combination, was enhanced by UTX
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TBX5 KDM6A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 673871 |
Curated By
- BioGRID