MYSM1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SMARCA4
Gene Ontology Biological Process
- ATP catabolic process [IMP, ISO]
- ATP-dependent chromatin remodeling [ISO]
- DNA methylation on cytosine within a CG sequence [IMP]
- aortic smooth muscle cell differentiation [IMP]
- blastocyst growth [IMP]
- blastocyst hatching [IMP]
- blood vessel development [IMP]
- cell morphogenesis [IMP]
- chromatin remodeling [IMP, ISO]
- definitive erythrocyte differentiation [IMP]
- embryonic hindlimb morphogenesis [IMP]
- embryonic organ morphogenesis [IMP]
- epidermis morphogenesis [IMP]
- extracellular matrix organization [IMP]
- forebrain development [IMP]
- glial cell fate determination [IMP]
- heart development [IMP]
- heart trabecula formation [IGI]
- hindbrain development [IMP]
- histone H3 acetylation [IMP]
- in utero embryonic development [IMP]
- keratinocyte differentiation [IMP]
- lens fiber cell development [IMP]
- liver development [IMP]
- methylation-dependent chromatin silencing [IDA]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell growth [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [ISO]
- nervous system development [IMP]
- neurogenesis [IDA]
- nucleosome assembly [TAS]
- nucleosome disassembly [ISO]
- outflow tract morphogenesis [IMP]
- pharyngeal arch artery morphogenesis [IMP]
- positive regulation by host of viral transcription [ISO]
- positive regulation of DNA binding [IGI]
- positive regulation of Wnt signaling pathway [IMP, ISO]
- positive regulation of cell differentiation [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cell migration [IMP]
- stem cell maintenance [IMP]
- transcription from RNA polymerase II promoter [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- ATPase activity [IMP, TAS]
- DNA polymerase binding [IPI, ISO]
- DNA-dependent ATPase activity [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription coactivator activity [ISO]
- Tat protein binding [ISO]
- androgen receptor binding [ISO]
- chromatin binding [IDA, ISO]
- lysine-acetylated histone binding [ISO]
- nucleosomal DNA binding [ISO]
- p53 binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- transcription coactivator activity [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI]
- ATPase activity [IMP, TAS]
- DNA polymerase binding [IPI, ISO]
- DNA-dependent ATPase activity [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription coactivator activity [ISO]
- Tat protein binding [ISO]
- androgen receptor binding [ISO]
- chromatin binding [IDA, ISO]
- lysine-acetylated histone binding [ISO]
- nucleosomal DNA binding [ISO]
- p53 binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- transcription coactivator activity [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Control of B cell development by the histone H2A deubiquitinase MYSM1.
Epigenetic histone modifications play critical roles in the control of gene transcription. Recently, an increasing number of histone H2A deubiquitinases have been identified and characterized. However, the physiological functions for this entire group of histone H2A deubiquitinases remain unknown. In this study, we revealed that the histone H2A deubiquitinase MYSM1 plays an essential and intrinsic role in early B cell ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 7C.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MYSM1 SMARCA4 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 673893 |
Curated By
- BioGRID